MYC inhibitor DC-34( DC-34 )

Catalog No. M13083 CAS No. 1966107-70-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MYC inhibitor DC-34
Note

Research use only, not for human use.
Brief Description

MYC inhibitor DC-34 is a potent small molecule that selectively inhibits MYC at the transcriptional level only when a G-quadruplex (G4) is present in the promoter.
Description

MYC inhibitor DC-34 is a potent small molecule that selectively inhibits MYC at the transcriptional level only when a G-quadruplex (G4) is present in the promoter, binds to MYC G4 with Kd of 9.4 uM; does not transcriptionally downregulate several other G4-dependent genes to the same extent; binds independently to the MYC G4 3'and 5' ends, demonstrates cytotoxicity in L363 MM cells with IC50 of 3.5 uM.
In Vitro

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In Vivo

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Synonyms

DC-34
Pathway

Cell Cycle/DNA Damage
Target

c-Myc
Recptor

c-Myc
Research Area

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Indication

——

CAS Number

1966107-70-9
Formula Weight

446.47
Molecular Formula

C24H25F3N2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C(C)OC2=CC=C(O)C(CN3CCCCCC3)=C12)NC4=CC=C(C(F)(F)F)C=C4
Chemical Name

4-(azepan-1-ylmethyl)-5-hydroxy-2-methyl-N-(4-(trifluoromethyl)phenyl)benzofuran-3-carboxamide

1. Calabrese DR, et al. Nat Commun. 2018 Oct 12;9(1):4229. 2. Felsenstein KM, et al. ACS Chem Biol. 2016 Jan 15;11(1):139-48.

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